Ensure that your remote site setting named "MetadataAPI" is using your current instance or is correctly using your custom domain.
If your MetadataAPI is using an instance, similar to https://et4ae5.na40.visual.force.com, then you will want to ensure you update this to the new instance or update it to use your MyDomain.
Steps to access remote site settings needed (as follows)
In Classic, navigate to the Sales or Service Cloud Setup menu
In Lightning, navigate to the Sales or Service Cloud Setup menu
If you are using a custom domain and this is already reflected in your Remote Site Settings, then no action is required.
Note: Additional information for customers who are preparing for a Sandbox Refresh while integrated via Marketing Cloud Connect or have performed a Refresh while integrated can be found below:
Marketing Cloud Connector stops working after Salesforce sandbox refresh (UAT refresh)
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