Marketing Cloud Delete Data Extensions in bulk with SSJS

In the business unit in which you need to delete data extensions make the following DE

Name: DEtoDelete
External Key: DEtoDelete
 

Populate the DE with the DE names which need to be deleted.

Create an SSJS activity with the following code

<script runat="server">
  Platform.Load("core", "1.1.1");
 
  var api = new Script.Util.WSProxy();
  var rowstoprocess = DataExtension.Init("DEtoDelete").Rows.Lookup(["isprocessed"],[0])
    
    for(j=0; j < rowstoprocess.length; j ++ ) 
 {
  var dataExtensionName = rowstoprocess[j].DEName

  var req = api.retrieve("DataExtension", ["CustomerKey"], {
   Property: "Name",
   SimpleOperator: "equals",
   Value: dataExtensionName
  });

  var customerKey = req.Results[0].CustomerKey;

  var res = api.deleteItem("DataExtension", { "CustomerKey":customerKey });

  DataExtension.Init('DEtoDelete').Rows.Update({"isprocessed": "1"}, ["DEName"], [dataExtensionName]);
 }
</script>